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An oral gel used for the prevention and the fight against gingival inflammations and other infections of the mouth.

About KLIRICH®

The oral mucosa can be the seat of pathologies considered as minor, such as inflammations, which cause bleeding of the gums, or ulcers. These cause discomfort and sometimes pain, bacterial diseases such as periodontal abscesses.
These pathologies can appear spontaneously or after a procedure in the dental practice.
There are few effective treatments for these minor pathologies.
Klirich has been developed in response to these inffections.


Advantages
  • Unique blend of natural ingredients with exceptional properties: anti-inflammatory, anti-bleeding, anti-microbial.
  • Helps to relieve sensitive gums.
  • Reduces thermal hypersensitivity (hot or cold)
  • Protecting gel film texture for better retention in the oral cavity.
  • Immediate and durable effect.
  • No feeling of discomfort during or after use.

Composition/ Main Ingredients/ Properties

NON Animal Based


Grapefruit Seed Extract

Grapefruit Seed Extract

Properties

  • A fast acting antimicrobial agent

Alchemilla Leaf Extract

Alchemilla Leaf Extract

Properties

Clove essential oil

Clove essential oil

Properties

Calendula Flower Extract

Calendula Flower Extract

Properties

Avocado oil

Avocado oil

Properties

1% Hyaluronic acid, High Molecular Weight (Biotechnology)

Hyaluronic acid is a natural constituent of connective tissue, especially in the gingival mucosa where it performs anti-oedematous and tissue repair functions. The physico-chemical properties of hyaluronic acid help to explain its anti-inflammatory properties.

Hyaluronic acid promotes and accelerates tissue reconstruction. It activates the migration of fibrocytes (cells contributing to tissue healing) and as a consequence healing is accelerated.

1% Hyaluronic acid, High Molecular Weight (Biotechnology)

Properties

  • Hyaluronan (HA) is a key component of the extra-cellular matrix. It is involved in several mechanisms of the wound healing process
  • Highly hygroscopic, like a sponge
  • Involved in the visco-elasticity of the skin.

1% Hyaluronic acid, High Molecular Weight (Biotechnology)

Bio-­‐technology origin

  • Bacteria are removed and cultivated
  • Bacteria are destroyed, the biological medium diluted and filtered
  • The strands of Hyaluronic acid settle to the bottom (precipitation)
  • After purification and drying, we obtain Hyaluronic acid ready to use!

1% Hyaluronic acid, High Molecular Weight (Biotechnology)

Reminder

  • The properties of this molecule depend on its molecular weight
  • Klirich 5000 KDa
  • HIGH MOLECULAR WEIGHT
  • STRUCTURAL PROPERTIES
  • HA degradation products (oligomers) stimulate endothelial cell proliferation and migration.
  • HA oligomers modulate inflammatory processes and promote neo-angiogenesis during the different steps of wound healing.

Treatable Cases

The Different Uses For KLIRICH®

3 daily massages of 15 seconds and leave it on inflamed site

Periodontal And Peri-implant Treatments
Post-scaling/planing

Reduces post scaling and root planing gingival inflammations.

Decongests the gums and mucosa.

Gingivitis/ Mucositis

Prevention and treatment of gingival inflammations around the teeth and implants.

Visible eff ect from the first 24 hours.

Periodontitis

Prevention of peri-implantitis.

Significantly and quickly reduces symptoms.

Treatments of Ulcers
Under Prosthesis

Treatment of aphthae and mouth ulcers on infl ammatory ridges or any type of mucosa.

Reduces 99 to 99.99 % of the tested microorganisms* in the mouth.Acts from the first 24 hours.

Ortho

Treatment of mechanical injuries related in particular to braces.

Reduces 99 to 99.99 % of the tested microorganisms* in the mouth.Acts from the first 24 hours.

Clinical Efficacy Test

KLIRICH® destroys
99,900 to 99,999%
of the tested microorganisms.

Result of an in vitro study vs placebo



Clinical Trial To Evaluate The Efficacy Of A Medical Device In The Decrease Of Gingival Inflammation Compared To A Placebo

Clinical Investigation Report according to ISO Standard #14155: 2011
Date and report: 22/01/2016
Clinical report available upon request

References
  1. AFNOR (2012) ISO 11930 international standard: Evaluation of the antimicrobial protection of a cosmetic product, Classification index: T75-600
  2. AFNOR (2013) EN 13624 European standard- Quantitative suspension test for the evaluation of fungicidal or yeasticidal activity in the medical area, Classification index: T 72-600
  3. AFNOR (2013) EN 13727 European standard- Quantitative suspension test for the evaluation of bactericidal activity in the medical area, Classification index: T 72-175
  4. AFNOR (2007) EN 14561 European standard- Quantitative carrier test for the evaluation of bactericidal activity for instruments used in the medical area, Classification index : T72-602
  5. AFNOR (2006) EN 14562 European standard- Quantitative carrier test for the evaluation of fungicidal or yeasticidal activity for instruments used in the medical area, Classification index: T72-206
  6. AFNOR (2015) EN 14476 European standard- Quantitative suspension test for the evaluation of virucidal activity in the medical area, Classification index: T 72-185
  7. Allen DR, Davies R, Bradshaw B, Ellwood R, Simone AJ, Robinson R, Mukerjee C, Petrone ME, Chaknis P, Volpe AR, Proskin HM. (1998) Efficacy of a mouthrinse containing 0.05% cetylpyridinium chloride for the control of plaque and gingivitis: a 6-month clinical study in adults. Howard University College of Dentistry, Washington, DC, USA.
  8. A. Scheie (1989) Modes of action of currently known chemical antiplaque agents other than chlorhexidine, in Dent Res 1989; 68:1609-1616. Cat 2
  9. C. Michel, S. Brousse, J. Luc, C. Roques (2005) In vitro comparison of the bactericidal and fungicidal mouthwash activity in conditions similar to their use, in Rev Odont Stomat 2005 ;34 :193-203.
    Laboratoire de bactériologie, virologie et microbiologie industrielle, Fonderephar; UFR des sciences pharmaceutiques de Toulouse.
  10. F.A Pitten, A. Kramer (2001) Efficacy of chlorure de cétylpyridinium used as oropharyngeal antiseptic. Arznzeim. Forsch, in Drug Res 2001;51:588-595. Cat 1
  11. J. Donabed, T. Rodrigues, T. Shaver, J. Howarth (2013) Novel Quat test method for successful application of cetylpyridinium chloride (CPC). In Envirotech July 29, 2013.
  12. J. Hegde, K. BAshetty, Krishnakumar, U. Gulati (2012) Quantity of sodium thisulfate required to neutralize various concentrations of sodium hypochlorite. In Asian Jourrnal of pharmaceutical and health sciences, Jul-Sep 2012, Vol 2.
  13. J.M.Tanzer, Y.Reid, W.Reid (1972) Method for preclinical evaluation of antiplaque agents, in Antimicrobial agents and chemotherapy vol. 1, May 1972, p.376-380.
  14. J.van Houte, D.B. Green (1974) Relationship between the concentration of bacteria in saliva and the colonization of teeth in humans. In infect Immun. Apr 9(4): 624-630.
  15. C. Roques, DR. S. Pecastaings, C. Michel (2012) Bain de bouche associant dig luconate de chlorhexidine et chlorure de cétylpyridinium: démonstration in vitro de ses avantages en termes de propriétés antimicrobiennes et de contrôle de plaque, dans Rev Odont Stomat 2012; 41:174-189. Laboratoire de bactériologie, virologie et microbiologie industrielle; UFR des sciences pharmaceutiques de Toulouse.
  16. S. Mankodi, K.Bauroth, J.J.Witt, S.Bsoul (2005) A 6-months clinical to study the effects of cetylpyridinium chloride mouthrinse on gingivitis and plaque, In AM J Dent 2005; 18: 9A-14A.
  17. S. Sheen, M.Eisenburger, M.Addy (2003) Effect of toothpaste on the plaque inhibitory properties of a chlorure de cétylpyridinium mouth rinse, in J Clin Periodont 2003;30:255-260. Cat 1.

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